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| Carnitine-acylcarnitine translocase ： ウィキペディア英語版 |
Carnitine-acylcarnitine translocase
Carnitine-acylcarnitine translocase is responsible for transporting both carnitine-fatty acid complexes and carnitine across the inner mitochondrial membrane.
==Function==
This enzyme is required since fatty acids cannot cross the mitochondrial membranes without assistance. The fatty acid is firstly bound to CoA and may cross the external mitochondrial membrane. It then exchanges the CoA for carnitine by the action of the enzyme carnitine palmitoyltransferase I. The complex then enters the mitochondrial matrix thanks to facilitated diffusion by carnitine-acylcarnitine translocase. Here, the acyl-cartinine complex is disrupted by carnitine palmitoyltransferase II and the fatty acid rebinds to CoA. Carnitine then diffuses back across the membrane by carnitine-acylcarnitine translocase into the mitochondrial intermembrane space. This is called the carnitine shuttle system.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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